Chronic administration of beta-blockers (a class of medications used for the
treatment of high blood pressure) may reduce the production of melatonin by the
body. However, this effect has not been shown to affect sleep patterns
(melatonin helps to regulate the body’s sleep cycles).
Melatonin may reduce the effectiveness of blood pressure medications like
methoxamine and clonidine. Consult with your healthcare provider before using
melatonin if you take these medications.
Non-steroidal anti-inflammatory medications like ibuprofen may reduce the
levels of melatonin in the blood. Reduced melatonin levels could alter sleep
patterns; consult your health care provider before taking melatonin supplements
if you are taking these medications.
Melatonin supplementation may increase the adverse side effects of
methamphetamine. Talk to your health care provider before using melatonin while
you are taking this medication.
