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Antibiotics - Tetracycline Derivatives
Nutrients
Depleted by Antibiotics
Tetracycline Derivatives
Nutrients Depleted
Calcium3,4
Osteoporosis (bone loss) is the primary symptom associated with chronic calcium
deficiency. Depleted levels can also cause muscle cramps, numbness and tingling,
joint pain, brittle nails, and tooth decay.7,10,11
Magnesium3,4
Symptoms of deficiency may develop within weeks and include anorexia, nausea,
vomiting, lethargy, and weakness. Severe deficiency may take months to appear
and is associated with muscle cramps, irritability, heart irregularities, and
mental confusion.7,9,10
Probiotics / Enterobiotics1
Probiotics refer to two or more organisms that enhance each other's growth,
living in balance with one another. Altering the balance of organisms that
naturally reside in the gastrointestinal tract may reduce resistance to
infections and diseases. Symptoms of deficiency include gas, abdominal distress,
diarrhea, and yeast infections.6
Vitamin B12
(Cobalamin)5
Deficiency is associated with anemia, neurologic symptoms like tingling (pins
and needles) or diminished sensory perception, sore tongue, weakness,
irritability, confusion, impaired memory, and personality
changes.7,9,11
Vitamin B6
(Pyridoxine)5
Symptoms of deficiency can develop in a relatively short period of time. They
include confusion, irritability, depression, inflammation of the mouth and
tongue, reddened lips, cracks at the corners of the mouth, and anemia. Over the
long term, low levels of this vitamin may lead to artherosclerosis (cholesterol
plaques) along blood vessel walls, which contributes to the development of heart
disease.7,8,11
Vitamin
K2
The major symptom of deficiency is an inability of the blood to clot properly,
which may lead to excessive bleeding. Another symptom is easy bruisability.
Depending on the cause of the deficiency, symptoms may appear in as early as 7
to 10 days.7,8,9,11
Zinc3,4
Signs and symptoms of deficiency include loss of appetite, fatigue, growth
retardation, skin and nail changes, diminished libido, impotence, increased
susceptibility to infection, poor wound healing, and loss of sense of
smell.7,9,11
Editorial Note
The selected depletions information presented here identifies
some of the nutrients that may be depleted by certain medications. The signs and
symptoms associated with nutrient deficiency may also indicate conditions other
than nutrient deficiency. If you are experiencing any of the signs or symptoms
mentioned, it does not necessarily mean that you are nutrient deficient.
Nutrient depletion depends upon a number of factors, including your medical
history, diet, and lifestyle as well as the length of time you have been taking
the medication. Please consult your healthcare provider; he or she can best
assess and address your individual healthcare needs, and determine if you are at
risk for nutrient depletions from these medications as well as others not listed
here. References
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1. | Shahani, KM. and Ayelo, AD. Rise of dietary Lactobacilli in
gastrointestinal microecology. Am. J. Clin. Nutr. 33:2448-2457,
1980. |
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2. | Conly, J. and Stein, K. Reduction of vitamin K2 concentrations in human
liver associated with the use of broad spectrum antimicrobials. Clin.
Invest. Med. 17(6):531-539, 1994. |
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3. | Roe, DA. Diet and Drug Interactions. New York, Van Nostrand
Reinhold, p. 87, 1989. |
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4. | Brion, M. et al. Metal ion-tetracycline interactions in biological
fluids. Part 5. Formation of zinc complexes with tetracycline and some of its
derivatives and assessment of their biological significance. Agent
Actions 17(2):229-242, 1985. |
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5. | Robinson, C. and Weigley, E. Basic Nutrition and Diet Therapy.
New York, MacMillan, pp. 46-54, 1984. |
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6. | Galland, L. The Four Pillars of Healing. New York, Random House,
pp. 186-199, 1997. |
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7. | Fauci, A. ed. et. al. Harrison's Principles of Internal
Medicine. Fourteenth Edition. New York, Mc-Graw-Hill Companies Health
Professional Division, 1998. |
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8. | International Life Sciences Institute, Present Knowledge in
Nutrition. Seventh Edition. Washington, DC, ILSI Press,
1996. |
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9. | National Research Council, Recommended Dietary Allowances. Tenth
Edition. Washington, DC, National Academy Press, 1989. |
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10. | Institute of Medicine, Dietary Reference Intakes. Washington,
DC, National Academy Press, 1997. |
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11. | Kirschmann, G. and Kirschmann, J. Nutrition Almanac. Fourth
Edition. McGraw-Hill, 1996.
Copyright © 2000 Integrative Medicine
Communications
The publisher does not accept any responsibility for the
accuracy of the information or the consequences arising from the application,
use, or misuse of any of the information contained herein, including any injury
and/or damage to any person or property as a matter of product liability,
negligence, or otherwise. No warranty, expressed or implied, is made in regard
to the contents of this material. No claims or endorsements are made for any
drugs or compounds currently marketed or in investigative use. This material is
not intended as a guide to self-medication. The reader is advised to discuss the
information provided here with a doctor, pharmacist, nurse, or other authorized
healthcare practitioner and to check product information (including package
inserts) regarding dosage, precautions, warnings, interactions, and
contraindications before administering any drug, herb, or supplement discussed
herein.
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