Drugs that Deplete Vitamin B12 (Cobalamin)

Antibiotics

  Aminoglycosides

• Gentamicin
• Neomycin
• Tobramycin

  Tetracycline Derivatives

• Doxycycline
• Minocycline
• Tetracycline

Anticonvulsant Medications

  Barbiturates

• Phenobarbital

  Hydantoin

• Fosphenytoin
• Phenytoin

Antidiabetic Medications

  Biguanides

• Metformin

Cardiovascular Medications

  Potassium Supplements

• Potassium Chloride

Cholesterol-Lowering Drugs

  Bile Acid Sequestrants

• Cholestyramine
• Colestipol

Female Hormones

  Oral Contraceptives

• Ethinyl Estradiol and Desogestrel
• Ethinyl Estradiol and Ethynodiol Diacetate
• Ethinyl Estradiol and Levonorgestrel
• Ethinyl Estradiol and Norethindrone
• Ethinyl Estradiol and Norgestimate
• Ethinyl Estradiol and Norgestrel
• Mestranol and Norethindrone
• Mestranol and Norethynodrel

Gout Medications

  Uricosuric Agents

• Colchicine

Ulcer Medications

  Histamine H-2 Antagonists

• Cimetidine
• Famotidine
• Nizatidine
• Ranitidine Bismuth Citrate
• Ranitidine Hydrochloride

  Proton Pump Inhibitors

• Lansoprazole
• Omeprazole