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  Chlorotrianisene

Chlorotrianisene

Pronunciation

(klor oh trye AN i seen)

Brand Names

TACE®

Therapeutic Categories

Estrogen Derivative, Oral

What is this medicine used for?

  • This medicine is used to stop/reduce the symptoms of menopause, especially hot flashes, vaginal dryness, itching, and burning.
  • It is used to treat female hypogonadism.
  • Rarely, it is used for the treatment of prostate cancer.

How does it work?

  • After menopause, when the body no longer produces estrogen, chlorotrianisene is used as a simple replacement of estrogen.

How is it best taken?

  • Take with food at a similar time every day or as directed by your healthcare provider. There may be days when you will not take the medicine.

What do I do if I miss a dose?

  • Take a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed one. Return to your regular schedule.
  • Do not take a double dose or extra doses.
  • Do not change dose or stop taking medicine without talking with healthcare provider.

What are the precautions when taking this medicine?

  • This medicine does not treat depression or nervous problems.
  • Limit alcohol intake (includes wine, beer, and liquor). May increase risk of breast cancer.
  • Do not use if you have unusual vaginal bleeding that has not been examined by healthcare provider.
  • Use caution if you have a weakened heart or high blood pressure. Talk with healthcare provider.
  • Tell your healthcare provider if you have ever had any blood clots in your legs, arms, or lungs.
  • There may be a higher risk of endometrial/breast cancer. Talk with healthcare provider.
  • Do not use if you have had breast or uterine cancer or if someone in your family (sister, mother, aunt) has had breast cancer. Talk with healthcare provider.
  • Do not take if allergic to the dye tartrazine (yellow). This is seen more often in people allergic to aspirin.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, throat; or any other symptoms involved.
  • Do not use in pregnancy and do not get pregnant. Use birth control that you can trust during use of this medicine and for 1 month after stopping it.
  • Do not use if you are breast-feeding.

What are the common side effects of this medicine?

  • Headache. Mild pain medicine may help.
  • Belly pain and cramps.
  • Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard candy, or chewing gum may help.
  • Breast enlargement/tenderness.
  • For women, vaginal bleeding (breakthrough bleeding, spotting) may occur.
  • Change in sexual ability or desire. This can return to normal after medicine is stopped. Talk with healthcare provider about other medicines without this side effect.

What should I monitor?

  • For women, periodic breast (monthly self-exams) and gynecologic exams are important.
  • Follow diet plan (calcium and vitamin D supplementation) and exercise program as recommended by healthcare provider.
  • Follow up with healthcare provider at least every year. Talk about duration of treatment.

Reasons to call healthcare provider immediately

  • Signs of a life-threatening reaction. These include wheezing; tightness in the chest; fever; itching; bad cough; blue skin color; fits; swelling of face, lips, tongue, or throat.
  • Severe headache.
  • For women, unusual vaginal bleeding. This includes lots of bleeding, spotting, or bleeding between cycles.
  • Severe nausea, vomiting, and/or diarrhea.
  • Any rash.
  • Swelling/pain of a leg or arm, sudden shortness of breath, difficulty breathing, chest pain.
  • A lump in the breast.
  • Any rash.

How should I store this medicine?

  • Store in a dry place at room temperature.

General statements

  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, herbal/supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, pharmacist, physician assistant).
  • Read the package insert for more details (given with the medicine).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter or natural products (herbs, vitamins).

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