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Anti-inflammatory Agents - Salicylic Acid Derivatives (2)
Nutrients
Depleted by Anti-inflammatory Agents
Salicylic Acid Derivatives
Nutrients Depleted
Iron4
Deficiency of this nutrient causes anemia. Iron-deficiency anemia may be
associated with pale coloring, fatigue, apathy, lethargy, and even difficulty
breathing. Mild deficiency may cause constipation and nail changes, including
brittle nails and nail ridges.6,7,8,9
Note: Iron loss is secondary to bleeding.
Potassium5
Symptoms of deficiency include anorexia, nausea, drowsiness, fatigue, muscle
pain, and weakness (usually of the lower extremities). Severe cases may lead to
heart irregularities and respiratory difficulties.6,8
Vitamin B9 (Folic
Acid)1,2
Effects of deficiency include increased incidence of certain birth defects.
Prolonged deficiency leads to anemia and possibly heart
disease.6,7,8
Vitamin C
(Ascorbic Acid)3
Symptoms associated with vitamin C deficiency include dry hair, gum disorders,
increased susceptibility to infections, and slow wound healing. Extreme
deficiency leads to scurvy, a condition characterized by anorexia, anemia,
swollen and bleeding gums, fatigue, and lethargy. Scurvy rarely occurs these
days because of the wide availability of vitamin C from dietary
sources.6,7,8,9
Editorial Note
The selected depletions information presented here identifies
some of the nutrients that may be depleted by certain medications. The signs and
symptoms associated with nutrient deficiency may also indicate conditions other
than nutrient deficiency. If you are experiencing any of the signs or symptoms
mentioned, it does not necessarily mean that you are nutrient deficient.
Nutrient depletion depends upon a number of factors, including your medical
history, diet, and lifestyle as well as the length of time you have been taking
the medication. Please consult your healthcare provider; he or she can best
assess and address your individual healthcare needs, and determine if you are at
risk for nutrient depletions from these medications as well as others not listed
here. References
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1. | Selhub, J. et al. Inhibition of folate enzymes by sulfasalazine. J.
Clin. Invest. 61:221-224, 1978. |
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2. | Lawrence, VA. et al. Aspirin and folate binding: in vivo and in vitro
studies of serum binding and urinary excretion of endogenous folate. J. Lab.
Clin. Med. 103:944-948, 1984. |
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3. | Coffey, G. and Wilson, CWM. Ascorbic acid deficiency and
aspirin-induced haematemesis. Brit. Med. J. I: 208,
1975. |
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4. | Leonards, JH. and Levy, G. Gastrointestinal blood loss during prolonged
aspirin administration. New Engl. J. Med. 289:1020-1022,
1973. |
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5. | Smith, MJH. and Smith, PK. eds. The Salicylates: A Critical
Bibliographic Review. New York, Interscience, 1966. |
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6. | Fauci, A. ed. et. al. Harrison's Principles of Internal
Medicine. Fourteenth Edition. New York, Mc-Graw-Hill Companies Health
Professional Division, 1998. |
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7. | International Life Sciences Institute, Present Knowledge in
Nutrition. Seventh Edition. Washington, DC, ILSI Press,
1996. |
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8. | National Research Council, Recommended Dietary Allowances. Tenth
Edition. Washington, DC, National Academy Press, 1989. |
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9. | Kirschmann, G. and Kirschmann, J. Nutrition Almanac. Fourth
Edition. McGraw-Hill, 1996.
Copyright © 2000 Integrative Medicine
Communications
The publisher does not accept any responsibility for the
accuracy of the information or the consequences arising from the application,
use, or misuse of any of the information contained herein, including any injury
and/or damage to any person or property as a matter of product liability,
negligence, or otherwise. No warranty, expressed or implied, is made in regard
to the contents of this material. No claims or endorsements are made for any
drugs or compounds currently marketed or in investigative use. This material is
not intended as a guide to self-medication. The reader is advised to discuss the
information provided here with a doctor, pharmacist, nurse, or other authorized
healthcare practitioner and to check product information (including package
inserts) regarding dosage, precautions, warnings, interactions, and
contraindications before administering any drug, herb, or supplement discussed
herein.
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