Nonsteroidal Anti-inflammatory Drugs

• Indomethacin

Nutrients Depleted

Iron³
Deficiency of this nutrient causes anemia. Iron-deficiency anemia may be associated with pale coloring, fatigue, apathy, lethargy, and even difficulty breathing. Mild deficiency may cause constipation and nail changes, including brittle nails and nail ridges.^5,6,7,8

Note: Iron loss is secondary to bleeding.

Protein / Amino Acids⁴
Symptoms of deficiency include stunted growth, poor muscle development or loss of muscle mass, hair loss, joint swelling, sluggishness, weakness, increased susceptibility to infection, and impaired wound healing.^7,8

Vitamin B9 (Folic Acid)¹
Effects of deficiency include increased incidence of certain birth defects. Prolonged deficiency leads to anemia and possibly heart disease.^5,6,7

Vitamin C (Ascorbic Acid)²
Symptoms associated with vitamin C deficiency include dry hair, gum disorders, increased susceptibility to infections, and slow wound healing. Extreme deficiency leads to scurvy, a condition characterized by anorexia, anemia, swollen and bleeding gums, fatigue, and lethargy. Scurvy rarely occurs these days because of the wide availability of vitamin C from dietary sources.^5,6,7,8

Editorial Note

The selected depletions information presented here identifies some of the nutrients that may be depleted by certain medications. The signs and symptoms associated with nutrient deficiency may also indicate conditions other than nutrient deficiency. If you are experiencing any of the signs or symptoms mentioned, it does not necessarily mean that you are nutrient deficient. Nutrient depletion depends upon a number of factors, including your medical history, diet, and lifestyle as well as the length of time you have been taking the medication. Please consult your healthcare provider; he or she can best assess and address your individual healthcare needs, and determine if you are at risk for nutrient depletions from these medications as well as others not listed here.