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ALTERNATIVE DOCTOR, LLC
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GARLIC
The pungent odor of garlic, which is offensive to some people, is noticeable on your breath and even your skin after you eat it. Despite this, herbalists worldwide consider garlic one of the most important herbal medicines. It has been used as both food and medicine in many cultures for thousands of years. The construction workers who built the Egyptian pyramids ate large amounts of garlic to protect themselves from diseases. Gravediggers in early eighteenth-century France drank a concoction of crushed garlic in wine to keep them from getting a plague that killed many people in Europe. During both World War I and II, soldiers were given garlic to prevent gangrene. Plant Description Garlic originally came from central Asia, and is now found throughout the world. Garlic is a perennial that can grow two feet high or more. The most important part of this plant for medicinal purposes is the compound bulb. Each bulb is made up of 4 to 20 cloves, and each clove weighs about 1 gram. What's It Made Of? The main active ingredient in garlic is alliin. Alliin is an odorless chemical relative of the sulfur-containing amino acid cysteine. When garlic bulbs are crushed, alliin is converted into another compound called allicin. Allicin is the active compound that gives garlic its characteristic odor and many of its healing benefits. Fresh garlic contains about 0.25 to 1.15 percent of allicin. The total amount of sulfur-containing substances in garlic is about 25 to 35 percent after the bulbs have been crushed. Allicin gives garlic its antibiotic effects. Allicin also helps lower cholesterol by blocking cells from making more cholesterol. Ajoene is another important active compound in garlic that helps prevent hardening of the arteries and stroke. Available Forms Garlic products are made from whole fresh garlic, fresh or dried garlic cloves, or oil of garlic. But the amount of allicin in commercial products can vary, depending on how the product was prepared, or on the percentage of active compounds in fresh garlic cloves. Not all garlic starts with the same amount of active ingredients. Aged garlic products are made by fermenting garlic. These products are odor-free, but they don't have many health benefits. Fermentation inactivates most of the active ingredients, so it's important that you carefully read the label on all garlic products. It is best to use standardized garlic products to be sure you're getting a specified concentration of allicin and other active substances. How to Take It For years, people have taken garlic to help prevent atherosclerosis (hardening of the arteries) and high blood pressure, colds, coughs, bronchitis, gastrointestinal problems, and menstrual pain. Medical research shows that garlic can kill many types of bacteria, some viruses and fungal infections, and even intestinal parasites. Garlic is also an antioxidant and it can boost your immune system. Garlic may even help prevent cancer. But garlic is best known for its favorable effects on cardiovascular health. Garlic is effective in treating and preventing high cholesterol and triglyceride levels, atherosclerosis, and respiratory infections such as colds and cough. You can take garlic in the following forms to help prevent cardiovascular problems and the common cold.
Precautions Avoid eating too much garlic because it might give you a stomachache. Also, if you handle too much fresh or dried garlic, you might get burn-like skin lesions or other skin irritations. If you know that your blood clots slowly, don't take large therapeutic doses of garlic. This is especially important if you're going to have surgery. Too much garlic can increase your risk for bleeding during or after the operation. If you're pregnant or nursing, talk to your health care provider before taking or eating large amounts of garlic. In small amounts, it's fine, but extremely large doses can stimulate the uterus and may even cause a miscarriage. Possible Interactions Garlic has blood-thinning properties. Therefore, if you are taking anticoagulant (blood-thinning) medications such as aspirin, you should refrain from consuming large amounts of garlic, either fresh or commercially processed. Supporting Research Apitz-Castro R, Carbrera S, Cruz MR, et al. Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release reaction, and platelet ultrastructure. Thromb Res. 1983;32:155169. Augusti KT. Studies on the effect of allicin (diallyl disulfide-oxide) on alloxan diabetes. Experientia. 1975;31(11):12631265. Berthold, H.K. et al.. Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism. JAMA. 1998;279. Bordia A. Effect of garlic on human platelet aggregation in vitro. Atherosclerosis. 1978;30:355360. Bordia AK, Joshi JK, Sanadhya YD, et al. Effect of essential oil of garlic on serum fibrinolytic activity in patients with coronary artery disease. Atherosclerosis. 1977;28:155159. Bradley PR, ed. British Herbal Compendium. Dorset, England: British Herbal Medicine Association; 1992:1:105108. Chang MLW, Johnson MA. Effect of garlic on carbohydrate metabolism and lipid synthesis in rats. J Nutrition. 1980;110:931. DeSmet PAGM, Keller K, Hไnsel R, Chandler RF, eds. Adverse Effects of Herbal Drugs. Berlin, Germany: Springer-Verlag; 1997:235236. Gruenwald J, Brendler T, Jaenicke C et al, eds. PDR for Herbal Medicines. Montvale, NJ: Medical Economics Company 1998:940941. Kiesewetter, H; Jung F, Mrowietz C, et al. Effects of garlic on blood fluidity and fibrinolytic activity: a randomised, placebo-controlled, double-blind study. Br J Clin Pract. 1990;44:2429. Kim SG, Nam SY, Chung HC, et al. Enhanced effectiveness of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate in combination with garlic oil against experimental hepatic injury in rats and mice. J Pharm Pharmacol. 1995;47(8):678682. Lawson LD, Ransom DK, Hughes B. Inhibition of whole blood platelet aggregation by compounds in garlic clove extracts and commercial garlic products. Thromb Res. 1992;65(2):141156. Mader FH. Treatment of hyperlipidaemia with garlic-powder tablets. Evidence from the German Association of General Practitioners' multicentric placebo-controlled double-blind study. Arzneimittelforschung. October 1990;40:11111116. Makheja AN, Bailey JM. Anti-platelet constituents of garlic and onion. Agents Actions. 1990;29(34):360363. Makheja AN, Vanderhoek JY, Bailey JM. Inhibition of platelet aggregation and thromboxane synthesis by onion and garlic. Lancet. 1979;1(2):781. Mashour NH, Lin GI, Frishman WH. Herbal medicine for the treatment of cardiovascular disease. Arch Intern Med. 1998;158:22252234. Mohammed SF, Woodward SC. Characterization of a potent inhibitor of platelet aggregation and release reaction isolated from Allium sativum (garlic). Thromb Res. 1986;44:793806. Murray MT. The Healing Power of Herbs: The Enlightened Person's Guide to the Wonders of Medicinal Plants. Second Ed. Rocklin, Calif: Prima Publishing; 1995:121131. Newall C, Anderson L, Phillipson J. Herbal Medicines: A Guide for Health-care Professionals. London, England: Pharmaceutical Press; 1996:129133. Orekhov A, Tertov V, Sobenin I, Pivovorava E. Direct antiatherosclerosis-related effects of garlic. Ann Med. 1995;37:6365. Oshiba S, Sawau H, Tamada T, et al. Inhibitory effect of orally administered inclusion complex of garlic oil on platelet aggregation in man [in Japanese]. Igaku No Ayuma. 1990;155(3):199200. Pan XY, Li FQ, Yu RJ, et al. Experimental chemotherapy of human gastric cancer cell lines in vitro and in nude mice [in Chinese]. Chung-Hua Chung Liu Tsa Chih. 1988;10(1):1518. Rose KD, Croissant PD, Parliamennt CF, et al. Spontaneous spinal epidural hematoma with associated liver dysfunction from excessive garlic ingestion: a case report. Neurosurgery. 1990;26:880882. Schulz V, Hansel R, Tyler V. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. 3rd ed. Berlin, Germany: Springer-Verlag; 1998:107123. Silagy C, Neil A. Garlic as a lipid lowering agent-a meta-analysis. JR Coll Physicians Lond. 1994;28:3945. Steiner M, Khan AH, Holbert D, Lin RI. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Am J Clin Nutr. 1996;64:866870. Stockley IH. Drug Interactions. 4th ed. London, England: Pharmaceutical Press; 1996. Tyler V. Herbs of Choice: The Therapeutic Use of Phytomedicinals. Binghamton, NY: Pharmaceutical Products Press; 1994:104115. Tyler V. The Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed. Binghampton, NY: Pharmaceutical Products Press; 1993:139143. Warshafsky S, Kramer RS, Sivak SL. Effect of garlic on total serum cholesterol. Ann Intern Med. 1993;119:599605.
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