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SAW PALMETTO There are about 40 published studies on saw palmetto berries, which reduce
levels of substances that our bodies use to make hormones such as testosterone
and estrogen. While we associate testosterone with men and estrogen with women,
both men and women have testosterone and estrogen in their bodies, just in
different levels. For men, too much of a substance called dihydrotestosterone (DHT) has been
blamed for a disorder called benign prostatic hyperplasia (BPH). Estrogen may
also have something to do with it. In BPH, cells in the prostate gland (a tiny
gland that lies behind the urethra) grow too quickly. The gland swells and
presses on the urethra, so that it feels as if you constantly need to urinate. A
common prescription drug for BPH, Proscar, reduces DHT in order to slow or stop
BPH. Recently, researchers concluded that saw palmetto can be as effective as
Proscar in relieving certain symptoms of BPH such as urine flow, which is
reduced in BPH, and the constant feeling that you have to urinate. One
difference between the two therapies, however, is that Proscar can shrink the
size of the prostate, and saw palmetto can't. For this reason, if you have
chosen to try saw palmetto for your BPH symptoms, it is very important to do so
under the guidance of a health care provider, and to keep regular appointments
with him or her so that your progress can be monitored. Saw palmetto berries were not always used for BPH; Native Americans ate them
as part of their diet, and they were also used to increase libido. Plant Description Saw palmetto is a fan palm that can reach heights of 10 feet in warm
climates. In the United States, it grows in the warm climates of the southeast,
from South Carolina to Mississippi and throughout Florida. Lush, green leaves
fan out from thorny stems. The plant bears white flowers, which develop yellow
olive-like berries. The berries, when ripe, turn bluish-black and are dried for
medicinal use. What's It Made Of? Saw palmetto's active ingredients are fatty acids and plant sterols. However,
most likely the fatty acids and sterols are not the only part of the berries
that affect hormone production, and it will take more scientific study before we
know exactly how saw palmetto works. The berries also contain high-molecular-weight polysaccharides, which are
usually associated with either anti-inflammatory or immune-stimulant effects.
Available Forms You can buy saw palmetto as crude dried berries, tea, powdered capsules,
tablets, liquid tinctures, and liposterolic extracts. Look for products that say
on the labels that they are standardized and contain 85 to 95 percent fatty
acids and sterols. How to Take It Saw palmetto relieves symptoms of Stage I and II BPH. Common symptoms include
frequent need to urinate, a delay before you are able to urinate, dripping after
urinating, and having to get up numerous times throughout the night to urinate.
The majority of men over 60 are considered to have urinary symptoms attributable
to BPH, which can disturb sleep, affect self-confidence, cause constant
low-grade anxiety or even pain, and may progress to infections in the bladder or
kidneys. If you think you have BPH and your health care provider has suggested
that you try saw palmetto, try to keep track of how it affects you. It shouldn't
take long for you to notice whether it's helping you. The recommended dosages for Stages I and II BPH is 160 mg, two times a day,
of a fat-soluble saw palmetto extract, which has been standardized to contain 85
to 95 percent fatty acids and sterols. Precautions Saw palmetto is a very mild herb. Side effects are very rare and mild stomach
complaints are the only recorded reactions. The American Herbal Products
Association gives saw palmetto a class 1 safety rating, which means that it is
safe when used as directed. You should not try to self-diagnose, or self-medicate, BPH. Saw palmetto only
relieves the symptoms of BPH, despite the fact that it alters DHT production and
testosterone levels. It will not shrink the prostate. Your health care provider
should monitor the course of BPH. Saw palmetto should not be used during pregnancy or breast-feeding. Possible Interactions No harmful drug interactions have been reported. Supporting Research Blumenthal M, ed. The Complete German Commission E Monographs:Therapeutic
Guide to Herbal Medicine. Boston, Mass: Integrative Medicine Communications;
1998. Braeckman J. The extract of Serenoa repens in the treatment of benign
prostatic hyperplasia: A multicenter open study. Curr Therapeut Res
1994;55:776–785. Carilla E, Briley M, Fauran F, et al. Binding of Permixon, a new treatment
for prostatic benign hyperplasia, to the cytosolic androgen receptor in the rat
prostate. J Steroid Biochem 1984;20:521-523. Carraro JC, et al. Comparison of phytotherapy (Permixon) with finasteride in
the treatment of benign prostate hyperplasia: a randomized international study
of 1,098 patients. The Prostate. 1996;29(4):231-240. Champault G, Patel JC, Bonnard AM. A double-blind trial of an extract of the
plant Serenoa repens in benign prostatic hyperplasia. Br J Clin
Pharmacol. 1984;18:461-462. Di Silverio F, D'Eramo G, Lubrano C, et al. Evidence that Serenoa repens
extract displays an antiestrogenic activity in prostatic tissue of benign
prostatic hypertrophy patients. Eur Uro.1992;21:309-314. Goepel M, Hecker U, Krege S. Saw palmetto extracts potently and
noncompetitively inhibit human a1-adrenoceptors in vitro. Prostate.
1998;38(3):208–215. Miller LG. Herbal medicinals: selected clinical considerations focusing on
known or potential drug-herb interactions. Arch Intern Med.
1998;158(20):2200–2211. el-Sheikh M, Dakkak MR, Saddique A. The effect of permixon on androgen
receptors. Acta Obstet Gynecol Scand. 1988;67:397–399. Hutchens AR. Indian Herbalogy of North America. Boston, Mass:
Shambhala Publications; 1973:243–244. Leung A, Foster S. Encyclopedia of Common Natural Ingredients Used in
Food, Drugs, and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons;
1996:467–468. McGuffin M, Hobbs C, Upton R, Goldberg A. American Herbal Products
Association's Botanical Safety Handbook. Boca Raton, Fla: CRC Press; 1996. Murray MT. The Healing Power of Herbs: Tthe Enlightened Person's Guide to
the Wonders of Medicinal Plants. Rocklin, Calif: Prima Publishing; 1995. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for
Health-Care Professionals. London, England: The Pharmaceutical Press; 1996, Schulz V, Hänsel R, Tyler VE. Rational Phytotherapy: A Physicians' Guide
to Herbal Medicine. Berlin, Germany: Springer-Verlag; 1998. Sökeland J, Albrecht J. A combination of Sabal and Urtica
extracts vs. finasteride in BHP (stage I to II acc. to Alken): A comparison of
therapeutic efficacy in a one-year double-blind study. Urologe A.
1997;36:327–333. Mandressi A, et al. Treatment of uncomplicated benign prostatic hypertrophy
BPH by an extract of Serenoa Repens clinical results. J Endocrinol
Invest. 1987;10(suppl 2):49. Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of
benign prostatic hyperplasia: a systematic review. JAMA.
1998;280:1604–1609. Wood HC, Osol A. United States Dispensatory. 23rd ed. Philadelphia,
Pa: J.B. Lippincott; 1943;971–972. Copyright © 2000 Integrative Medicine Communications The publisher does not accept any responsibility for the
accuracy of the information or the consequences arising from the application,
use, or misuse of any of the information contained herein, including any injury
and/or damage to any person or property as a matter of product liability,
negligence, or otherwise. No warranty, expressed or implied, is made in regard
to the contents of this material. No claims or endorsements are made for any
drugs or compounds currently marketed or in investigative use. This material is
not intended as a guide to self-medication. The reader is advised to discuss the
information provided here with a doctor, pharmacist, nurse, or other authorized
healthcare practitioner and to check product information (including package
inserts) regarding dosage, precautions, warnings, interactions, and
contraindications before administering any drug, herb, or supplement discussed
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